X-Pulse: Revolutionizing Benchtop NMR Spectroscopy

X-Pulse represents a groundbreaking advancement in benchtop NMR spectroscopy, offering unmatched flexibility. Its distinctive modular design allows for fully tunable broadband X-nuclei capability, integration with flow chemistry, sample automation, reaction monitoring, and variable temperature control, all while delivering exceptional spectral resolution. X-Pulse caters to a broad spectrum of NMR chemical analysis needs, making it an ideal tool for research, development, quality control, and educational purposes directly in your laboratory.

The X-Pulse benchtop NMR spectrometer is designed to identify structures, characterize reaction dynamics, and measure the physical and chemical properties of various molecules, compounds, and mixtures. It can be conveniently placed in a laboratory without the need for liquid cryogens. Featuring a high homogeneity permanent magnet, X-Pulse offers exceptional temperature stability.

X-Pulse is compatible with standard 5mm NMR tubes and includes an easy-to-use flow cell. The optional X-Auto sample changer enhances throughput and automates data acquisition for up to 25 samples.

The new and improved SpinFlow software simplifies routine experiments and provides greater flexibility for advanced users.

Standard features include comprehensive pulsed field gradients and shaped RF pulses for coherence selection, selective excitation, and solvent suppression.

On resonance: In Conversation with Dr Dave EllisPlay

Video Credit: Oxford Instruments Magnetic Resonance

Broadband

X-Pulse is the world's only broadband benchtop NMR system, offering the unique capability to freely tune across a broad spectrum of X-Nuclei within a single benchtop instrument.

Resolution <0.35 Hz (50 %)/<10 Hz (0.55 %)

Sensitivity: 130:1 for 1 % Ethyl Benzene

X-Channel: Fully tuneable ^²⁹Si – ^³¹P

Pulsed field gradients as standard (>0.5 T/m)

Variable temperature option (0 °C – 65 °C)

Flow NMR option

No cryogens

Standard 5 mm OD NMR tubes

Easy to use

Image Credit: Oxford Instruments Magnetic Resonance

Dual X

Four NMR active nuclei can be analyzed with one device with the X-Pulse Dual-X benchtop NMR system.

Resolution <0.35 Hz (50 %)/<10 Hz (0.55 %)

Sensitivity: 130:1 for 1 % Ethyl Benzene

X-Channel: select 2 nuclei from ^¹³C, ^³¹P, ^⁷Li, ^²⁹Si, ^¹¹B, ^²³Na, and more

Pulsed field gradients as standard (>0.5 T/m)

Variable temperature option (0 °C – 65 °C)

Flow NMR option

No cryogens

Easy to use

Standard 5 mm OD NMR tubes

Fully upgradable to X-Pulse broadband

Image Credit: Oxford Instruments Magnetic Resonance

HF

The HF is a highly sensitivesingle channel benchtop NMR system with exceptional sensitivity.

Resolution <0.35 Hz (50 %)/<10 Hz (0.55 %)

Sensitivity: 200:1 for 1 % Ethyl Benzene

Pulsed field gradients as standard (>0.5 T/m)

Variable temperature option (0 °C – 65 °C)

Flow NMR option

No cryogens

Easy to use

Standard 5 mm OD NMR tubes

Fully upgradable to X-Pulse broadband or X-Pulse Dual-X

Image Credit: Oxford Instruments Magnetic Resonance

Choose the Nuclei

True broadband capability with the X-Pulse system grants users the flexibility to select the nuclei required for their experiments, whether it is ^¹H, ^¹³C, ^³¹P, ^⁷Li, ^²⁹Si, or even more exotic nuclei like ^¹²⁹Xe, ^¹¹B, or ^⁵⁹Co. Simply choose the desired nucleus in the software and adjust the probe to operate under optimal conditions.

Maximizing the signal-to-noise ratio is crucial for the success of many benchtop NMR experiments. The X-Pulse boasts exceptional sensitivity, achieving 130:1 (broadband/Dual-X) and 200:1 (HF) for 1 % ethyl benzene, making successful outcomes more attainable. For nuclei with low receptivity, such as ^¹³C or ^²⁹Si, sensitivity is of utmost importance. The ability to tune and match for each specific nucleus allows users to achieve the maximum signal-to-noise ratio

Image Credit: Oxford Instruments Magnetic Resonance

Powerful

X-Pulse is an exceptionally versatile and powerful benchtop NMR instrument. Its design philosophy, which separates the magnet and electronics similar to high-field NMR systems, allows for the independent maximization of key system components' performance. This results in a system capable of acquiring data using a vast array of NMR pulse sequences.

It supports standard 1-dimensional and 2-dimensional proton and X-nuclei experiments, such as FID, DEPT, HSQC, and HMBC, as well as more complex sequences like gs-HSQC, PGSE, and solvent suppression, utilizing 3-axis pulsed field gradients and shaped pulses.

These advanced NMR techniques can be combined with other instrument capabilities, such as the flow cell for in-line reaction monitoring or the variable temperature system, enabling users to gain new insights into chemistry directly in their laboratory.

Image Credit: Oxford Instruments Magnetic Resonance

High Resolution

With X-Pulse, separating NMR peaks becomes easier and detecting lower concentrations is more achievable.

The instrument features a 60 MHz (1.4T) permanent magnet and utilizes advanced shimming technology to generate an exceptionally homogeneous field. This results in a resolution of less than 0.35 Hz at half-height and a line shape of 10 Hz at 0.55 %. These capabilities make it easier to identify and integrate peaks.

Additionally, the combination of shaped RF pulses and effective solvent suppression enables the analysis of challenging compounds, such as sugars and starches dissolved in water.

Image Credit: Oxford Instruments Magnetic Resonance

Benchtop Convenience

The magnetic field of the X-Pulse benchtop NMR system is generated using a uniquely designed permanent magnet, eliminating the need for cryogens and thereby significantly reducing operating costs and concerns about magnet quenching.

This innovative magnet design ensures extremely high stability, resulting in artefact-free experiments. With a compact benchtop footprint and minimal stray field (2G line within the magnet case), the X-Pulse can be installed in a variety of environments without requiring special facilities. This allows for NMR experiments to be conducted right next to other laboratory work or even adjacent to a process reactor, enhancing the understanding of reaction processes.

The magnet’s large thermal mass ensures stable, artefact-free data collection, even when flowing liquids at temperatures ranging from 10 °C to 75 °C through the flow cell. Additionally, the optional X-Pulse mobile workstation provides the flexibility to easily move the system as needed.

Image Credit: Oxford Instruments Magnetic Resonance

Easy Operation

The new SpinFlow benchtop NMR data acquisition software enhances the ease of use for the X-Pulse system. Predefined "quick" experiments enable the collection of routine data, such as basic 1-dimensional ^¹H spectra or ^¹³C DEPT arrays, with a single click.

Additionally, the user-defined experiments feature allows experienced users to save their own sequences and parameters, turning any setup into a single-click experiment. This ensures consistency and reduces the time required for data collection. Experiment queues can be easily built and saved, automating multiple acquisitions on a sample and efficiently repeating this process across many samples, thereby maximizing efficiency and minimizing errors.

Image Credit: Oxford Instruments Magnetic Resonance

See X-Pulse in Action

New X-Pulse with X-AutoPlay

Video Credit: Oxford Instruments Magnetic Resonance

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